Epistasis GWAS for 7 common diseases

Data

Published by: Microsoft Research
Categories: Science & Statistics
Date added: 10/31/2012
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Results of SNP-pair epistasis GWAS (genome-wide association study) on the Wellcome Trust data. P values are based on a likelihood ratio test comparing the likelihood with a multiplicative term versus that for an additive linear model. 63.5 billion SNP pairs were evaluated for seven common diseases (type I diabetes, type II diabetes, coronary artery disease, hypertension, rheumatoid arthritis, Crohn’s disease, and bipolar disorder). If you need more results than can be provided here, please email a request to heckerma@microsoft.com, jennl@microsoft.com, and lippert@microsoft.com.

This study makes use of data generated by the Wellcome Trust Case-Control Consortium. A full list of the investigators who contributed to the generation of the data is available from www.wtccc.org.uk. Funding for the project was provided by the Wellcome Trust under award 076113 and 085475.

Service root URL

https://api.datamarket.azure.com/MicrosoftResearch/EpistasisGWAS/v1/

This service supports fixed query. Some queries may include required input parameters. (learn more about query types)

Compute

Input parameters:

Name Sample values Type Required
phenoType IBD String Required
snpOrGeneList1 rs1695824,rs10158678,rs2249097 String Required
snpOrGeneList2 rs1695824,rs10158678,rs2249097 String Required
pairLimit 1000 Int32

Results:

Name Type
GeneratedId Guid
Snp1 String
Snp2 String
Phenotype String
PValue String

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